Volume 16, No.1 Pages 42 - 43

4.SPring-8 通信/SPring-8 Communications

Interim Review Results of 2009A Long-term Proposals

(財)高輝度光科学研究センター 利用業務部 User Administration Division, JASRI

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1.Phase contrast X-ray imaging of the lung

〔実験責任者名〕Rob Lewis(Monash University)






   This proposal aims to carry out researches to identify better ways to ventilate very preterm infants and to study the onset and progression of adult lung diseases such as asthma, fibrosis and emphysema.  The employed technique is a propagation-based phase contrast imaging (PCI) at BL20B2.  So far, coordination of physical techniques and medical biology has shown many good results.  Especially the combination of PCI and particle image velocimetry (PIV) is a big outcome of this study.  Both temporal and spatial patterns of lung aeration at birth were imaged successfully in newborn rabbit and a mouse model of pulmonary fibrosis.  The expansion of the PIV technique to three dimensions is novel and expected to produce many publications.  Simultaneous PCI and iodine-based angiography to demonstrate the effect of lung aeration on pulmonary blood flow is also an interesting technique to explore.  The image processing software developed in collaboration with other group in Australia will be of great help to users of synchrotron imaging around the world.  By clarifying the mechanism of liquid removal in the lung of newborn rabbit and proposing a better ventilation method for preterm human infants, this study has already made a significant contribution to clinical medicine.  From the results and developments achieved so far, we are convinced that the second half of the research period will be more fruitful.



[1] A. B. te Pas, M. Siew, M. J. Wallace, M. J. Kitchen, A. Fouras, R. A. Lewis, N. Yagi, K. Uesugi, S. Donath, P. G. Davis, D. J. Morley and S. B. Hooper: “Establishing functional residual capacity at birth: the effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model” Pediatric Research 65 5 (2009) 537-541.

[2] A. Fouras, M. J. Kitchen, S. Dubsky, R. A. Lewis, S. B. Hooper and K. Hourigan: “The past, present and future of X-ray technology for in vivo imaging of function and form” Journal of Applied Physics 105 102009 (2009) 1–14.

[3] A. B. te Pas, M. Siew, M. J. Wallace, M. J. Kitchen, A. Fouras, R. A. Lewis, N. Yagi, K. Uesugi, S. Donath, P. G. Davis, D. J. Morley and S. B. Hooper: “Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits” Pediatric Research 66 3 (2009) 295-300.

[4] M. J. Kitchen, A. Habib, A. Fouras, S. Dubsky, R. A. Lewis, M. J. Wallace and S. B. Hooper: “A new design for high stability pressure-controlled ventilation for small animal lung imaging” Journal of Instrumentation 5 2 (2010) T02002.

[5] J. T. Pearson and R. A. Lewis: “Frontiers in research reviews: Synchrotron radiation for dynamic imaging of living systems” Clinical and Experimental Pharmacol Physiol 36 1 (2009) 84-87.

[6] S. B. Hooper, A. B. te Pas, R. A. Lewis and C. J. Morley: “Establishing functional residual capacity at birth” Neoreviews 11 (2010) 474-483.

[7] B. J. Allison, K. J. Crossley, S. J. Flecknoe, C. J. Morley, G. R. Polglase and S. B. Hooper: “Pulmonary hemodynamic responses to in utero ventilation in very immature fetal sheep” Respiratory Research 11 111 (2010).

[8] M. A. Beltran, D. M. Paganin, K. Uesugi and M. J. Kitchen: “2D and 3D X-ray phase retrieval of multi-material objects using a single defocus distance” Optics Express 18 7 (2010) 6423-6436.

[9] M. J. Kitchen, D. M. Paganin, K. Uesugi, B. J. Allison, R. A. Lewis, S. B. Hooper and K. M. Pavlov: “X-ray phase, absorption and scatter retrieval using two or more phase contrast images” Optics Express 18 19 (2010) 19994-20012.

[10] M. S. Islam, R. A. Lewis, K. Uesugi and M. J. Kitchen: “A high precision recipe for correcting images distorted by a tapered fiber optic” Journal of Instrumentation 5 (2010) 09008.




〔実験責任者名〕小野寺 宏(国立病院機構西多賀病院)












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